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    The choles-terol guideline stressed that adherence to lifestyle andto statin therapy should be re-emphasized before theaddition of a nonstatin drug is considered, as therewas not strong RCT evidence to support their routineuse.

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    Thisintestinal stem cell niche (zone of cell replication) is re-stricted to the lower one-halfofthe gland and contains highlyproliferative intermediate cells (as previously explained) andcells at various stages of differentiation. Therefore, when all of the IL-2 is used up or disappears, Tregsundergo apoptosis (Pandiyan 2008)

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